What is EGF?
First discovered in the 1980s, epidermal growth factor (EGF) is a polypeptide that is naturally found in body fluids such as – urine, saliva, milk and plasma. This powerful polypeptide exerts its regulatory effect on epidermal tissue repair by binding to epidermal growth factor receptor. This sets off a cell signaling cascade resulting in cell renewal and wound repair.
Medical applications of EGF
Along with several related peptide growth factors, EGF has been shown both in vivo and in vitro to accelerate events associated with epidermal wound repair.
EGF has been used to accelerate skin regeneration in burn victims as well as speed wound recovery in patients with diabetic foot ulcers.
Abundant in quantity along the gastrointestinal tract, EGF has also been found to exert a biological effect in the maintenance of mucosal integrity. Studies have shown that on top of its healing properties, it also has the ability to regulate gastric acid secretion as well as inhibit bacterial colonization in gastric ulcers!
Ophthalmic solutions containing EGF has been shown to be promising in the treatment oftraumatic corneal epithelial defects, with research trials showing that the use of solution significantly enhances the mean epithelial healing time.
In a nutshell, EGF acts as a healing factor for the body, aiding in the repair of skin, corneal, intestinal and mucosal wounds. While most medical applications of EGF are still in the experimental phase, the future of EGF in the world of wound therapy is brimming with potential.
Skincare benefits of EGF
As we age and reach our late twenties, the levels of EGF in the body start to sharply decline. This in turn results in a slower rate of skin repair, which means that the skin starts to get less resilient and signs of ageing starts to set in. A reduction in skin quality results in the loss of skin elasticity and loss of radiance resulting in dull crepey skin. Skin that is prone to pigmentation issues such as age spots and persistent acne marks is another sign of poor skin quality.
Consistent use of EGF products can help to restore your skin barrier, promote skin elasticity and thus improve the quality of skin. While skeptics may argue that the growth factor molecules are too large to penetrate the skin barrier, studies have shown that topical application of EGF alone can help to promote skin rejuvenation by stimulating fibroblast proliferation and increasing collagen production. One possible route of entry is through hair follicles and sweat glands. Chemical modification with lipophilic molecules can also help to improve penetration of growth factors into the skin.
To further enhance penetration into the skin, experts also suggest topical application after procedures such as microneedling or laser resurfacing.
Should I include EGF into my skincare routine?
The short answer is yes! While sunscreen, antioxidants and retinols still form the holy trinity in skincare, EGF is a useful adjunct to add to your antiaging skin care routine as it aids in the production of collagen and elastin.
Any skin type can benefit from incorporating EGF into their skin care routine. Unlike retinoids, EGF does not cause skin irritation and hence is suitable even for sensitive skin. Not only does it increase the thickness of your skin, it helps it retain water better by improving skin hydration resulting in more youthful bouncy skin.
How to use EGF
Most skincare experts recommend applying EGF as the first step of your skincare routine. It is best applied to damp skin, lightly tapping until fully absorbed before layering on other skincare products. For best results, avoid pairing EGF products with alpha hydroxy acids (AHAs) or vitamin C as the acidity can cause the growth factors to break down.
If you have AHAs or vitamin C in your skincare routine, you can consider alternating the products or applying one in the day and one in the night.
Daily topical application of EGF rich products such as the Ageless EGF repair serum will result in softer, smoother and more radiant skin. Revitalize your skin today with the newly formulated Ageless EGF repair serum exclusively available at Radium Medical Aesthetics.