5-Point Anti-Ageing Injectable [2024 ]

Radium Aesthetic

Aesthetic Treatments

Hybrid Cooperative Complex HA For Bio-Remodelling

Hybrid Cooperative Complex HA injectable for Skin Remodelling

This Hybrid Cooperative Complex HA injectable for bio-remodelling, also known as Profhilo, is a popular choice among aesthetic doctors in Singapore for addressing ageing skin concerns and enhancing facial features. The treatment stands out among the array of dermal fillers available in the region, as it primarily focuses on rejuvenating the skin’s texture and stimulating the production of collagen and elastin.

In Singapore, dermal fillers can generally be divided into two categories: temporary hyaluronic acid (HA) fillers and semi-permanent collagen-stimulating ones. 

Profhilo is an HA-based injectable, which can stay within the body for several months, providing lasting benefits before being naturally absorbed. Not only does it revitalise ageing skin but it allows for augmentation of facial features, such as lips, nose and cheeks, offering a comprehensive solution for those seeking to improve their appearance.

It was launched in Europe a few years ago. The properties of the injectable are distinctly different from dermal fillers. It uses a unique BAP or bio aesthetic points technique that drastically changed the way doctors treat skin ageing in middle-aged people. It has one of the highest HA (hyaluronic acid) concentrations in the market (64mg/2ml) – 5 times more than regular skinbooster. It is primarily used to stimulate the production of collagen, elastin, and adipocytes (fats) cells to combat skin laxity and signs of ageing.

How does The treatment work?

Step 1: Preparing The Skin

The treatment area is cleansed and, if necessary, numbed with a topical anaesthetic to ensure a comfortable experience during the injectable treatments.

Step 2: Administering Injections

The practitioner will carefully inject the solution, which contains a high concentration of hyaluronic acid, into the skin tissue. This hydrates and nourishes the skin, providing a skin lifting effect.

Step 3: Reacting With The Skin Tissue

As the solution interacts with the skin tissue, it boosts hydration, leading to improved skin texture and a subtle skin lifting effect. The unique concentration of hyaluronic acid also aids in skin rejuvenation.

Step 4: Collagen Stimulation And Elastin Production

Over the next few weeks, the production of 4 different types of collagen and elastin will be stimulated, improving skin laxity and giving your skin a smoother, more youthful appearance.

Step 5: Follow-Up Treatments

To achieve optimal results, a series of Profhilo injections may be recommended, with each session spaced a few weeks apart. This ensures a consistent increase in collagen and elastin production, further enhancing the skin’s texture and lifting effect.

Step 6: Maintenance And Aftercare

After completing the recommended number of injections, you can maintain your skin’s rejuvenated appearance with periodic touch-up sessions as advised by your practitioner. Proper skincare and sun protection are also crucial for preserving the effects of the treatment. 

What areas can The Injectable treat?

  • Face: Can be applied to multiple facial areas, such as the forehead, cheeks, chin, and eyes. The hyaluronic acid in the treatment helps to plump, firm, and hydrate the skin, resulting in a more youthful and radiant appearance.
  • Neck and décolletage: The neck and décolletage are often prone to wrinkles and skin laxity due to ageing and sun exposure. The treatment helps increase skin firmness in these areas through hydration, and collagen and elastin production.
  • Arms: As we age, the skin on our arms can lose firmness and elasticity, leading to sagging and a wrinkled appearance. This injectable skincare treatment can improve overall skin tone and hydration.
  • Knees: The skin around the knees can also show signs of ageing, with wrinkles and sagging becoming more prominent over time. By injecting hyaluronic acid, the knees’ skin can regain its youthful appearance, becoming smoother, firmer, and more hydrated.

Benefits of The 5-Point Anti-Ageing Injectable

Slow Down Skin Ageing

The injectable treatments effectively reverse and slow down the physiological process of skin ageing by offering the following benefits:

  • Increased Skin Hydration: The high concentration of hyaluronic acid helps to deeply hydrate the skin, making it appear more supple and plump.
  • Strengthening Elastic Fibres: It stimulates the production of elastin, which strengthens the skin’s elastic fibres, providing better resilience and firmness.
  • Improved Collagen Production: The treatment promotes collagen synthesis in the dermis, leading to a more youthful-looking skin and reduced signs of ageing

Skin Repair

The treatments also help repair dermal tissue by targeting skin issues like acne scars and chicken pox marks:

  • Stimulating Collagen Production: It encourages the production of collagen, which helps fill in depressed acne scars and improves the overall texture of the skin.
  • Reducing Scar Appearance: By repairing dermal tissue and promoting skin regeneration, the treatments can effectively reduce the appearance of acne scars and other skin imperfections.

Skin Lifting

Achieve face lifting and corrective results without surgical intervention:

  • Non-Invasive Treatment: Unlike surgical interventions, the treatments require minimal downtime and offer a less invasive alternative for those seeking skin lifting benefits.
  • Natural-Looking Results: By stimulating the skin’s natural repair processes and collagen production, it helps achieve a subtle, natural-looking lift and contour improvement.

Side effects of This Injectable Treatment

The treatment does not cause any long-term side effects as it is biocompatible with the body and can be broken down completely.

Immediately after the treatment, you may experience some swelling, bruising, and/or pinpoint bleeding at the injection points. These side effects should subside within 24 hours.


Cost of treatment in Singapore

Prices start from S$1,000. Price may vary slightly based on the doctor’s experience in administering filler treatments.

Differences between the 5-Point Anti-Ageing Injectable and other HA dermal fillers

NUMBER OF INJECTION POINTS Unlike other skin-hydrating treatments such as skinboosters that require many injection points on the face, this treatment only requires five entry points on the face.

CONCENTRATION OF HA 5-Point Anti-Ageing Injectable has one of the highest concentrations of HA (64mg/2ml) among the different types of injectables in the market. Not only does it boost the moisture content in the treated area by rehydrating the skin, it also remodels ageing and sagging skin.

CONTENT OF INJECTABLE PARTICLES 5-Point Anti-Ageing Injectable the only known HA injectable in the world that constitutes a buffered physiological solution of high molecular weight (H-HA) and low molecular weight (L-HA) HA. The H-HA and L-HA molecules interact with each other to provide a rheological property that allows the doctor to administer the treatment easily without increasing the viscosity of the injectable.

POST-TREATMENT CARE It is a low G-prime injectable that it disperses very quickly beneath the skin to the rest of the face after the treatment. It does not require any post-treatment massage as it has minimal risk of leaving lumps of nodules that won’t go away.

Frequently asked questions about The Treatment in Singapore

Who is a suitable candidate?

It is suitable for people who:

  • Display early signs of skin ageing such as fine lines and mild sagging skin, but with good volume on the face
  • Want to increase overall hydration to the skin without adding volume to specific areas of the face
  • Are looking to improve overall skin texture

Note: If you are over the age of 60 with heavy, saggy skin, you will achieve better skin-lifting and tightening result when you adopt a combination approach using thread lift, collagen-stimulating fillers, or Ultherapy.

How often should I undergo treatment?

During your initial treatment, it is advisable to undergo 2 treatments, each held 4 weeks apart. Once the initial 2 treatments are completed, you can repeat the treatment every 9 to 12 months.


Can the Injectable be combined with other treatments?
  • FOR SKIN LIFTING: It can be combined with treatments like Ultherapy or thread lift for a longer-lasting skin-lifting outcome.
  • FOR VOLUME LOSS: It can be combined with dermal fillers to plump up deficient areas for a more youthful appearance.
  • FOR SCAR TREATMENT: It works well with PicoSure laser to stimulate collagen and elastin production with precise, targeted treatment, causing minimal damage to the surrounding tissue.
Is there any downtime Associated with the treatment?

The downtime associated with 5-Point Anti-Ageing Injectable treatment is minimal. There may be some swelling and/or pinpoint bleeding following the injection, but these side effects should subside very quickly. You should be able to resume your daily activities after the treatment.

How Long Do The Injections Last?

The injections typically provide noticeable improvements in skin quality for about 6 to 12 months. However, individual results may vary, depending on factors such as skin condition, age, and lifestyle. 

Does The Injectable Treatment Change Your Face Shape?

The injectable treatments primarily focus on improving skin quality and providing subtle lifting effects. While the treatment can help to improve facial contours and firmness, it does not drastically change your face shape.


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    Induce skin remodelling for intensive skin repair
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    Reduce appearance of fine lines, wrinkles, and skin laxity
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    Visible improvement in skin laxity
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    Kickstart collagen production to reduce appearance of depressed scars
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    Reduce appearance of stretch marks on the arms, hips, tummy and thighs

Best For

It is suitable for a wide range of individuals who are looking to address concerns related to skin ageing, such as fine lines, wrinkles, and loss of skin elasticity.

It can also be administered on the body to improve skin laxity and stretch marks.

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