Polynucleotides Skin Therapy | Radium Medical Aesthetics Singapore

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Aesthetic Treatments

Polynucleotides (PN) Skin Therapy

Achieve Intense Skin Repair with DNA-Based Treatment

PN is a skin-healing treatment that has surged in popularity in recent months. It is also commonly referred to as Miracle Healer Injection, or 婴儿针.

What is Rejuran Healer?

Nucleotides put together form a long chain of polynucleotide, also known as DNA. Simply put, polynucleotide is DNA. These polynucleotides repair damaged, ageing skin cells, gradually improving the overall appearance of your complexion. It was first made popular in Asian countries such as Korea and Japan where smooth, luminous complexion was viewed as beautiful and healthy. The DNA extract in Rejuran Healer is obtained from salmon. Other than providing you omega-3 fatty acids if you consume the fish, salmon DNA possesses multiple benefits for the skin. Research has shown that salmon DNA is an effective key ingredient for addressing aging skin by rejuvenating and repairing the skin from inside.

What is Plinest?

Similar to Rejuran Healer, Plinest is a skin rejuvenation and regeneration treatment that uses pure and high quality polynucleotide gel. It is developed in Italy, extracting DNA fragments from Italian trout fish, using Masterlli’s HPT technology.

It has biostimulating and skin revitalising properties to kickstart collagen repair, giving you visible skin brightening, improvement in overall skin texture, and enhanced skin elasticty – reversing visible signs of skin ageing.

Several clinical studies have supported the evidence that it can repair damaged, ageing skin by stimulating the production of fibroblasts and collagen – which are essential building blocks for younger-looking skin.

In addition, it is particularly effective for people with fibrous scar tissue caused by old acne scars and stretch marks. This is because Plinest has hydrating, viscoelastic properties that can help to improve the appearance of uneven skin as soon as afte the first serssion of Plinest treatment. 

Why is DNA From Fish Extract used for skin rejuvenation?

A study was published in March 2010 to investigate the effect of rubbing salmon DNA on human skin. The results were astounding: Subjects showed a significant improvement in skin elasticity and skin texture. Unbeknownst to many, salmon DNA has very similar base structure with humans. PDRN is the component harvested from salmon’s DNA for the use of cosmetic application in skin treatments. PDRN is a substance that is found in newly formed tissues as its role is to repair damaged skin and reduce all signs of aging including wrinkles and fine lines.

Researchers have also found that salmon DNA is very safe and compatible with the use in human body without causing any adverse side effects.

What are the benefits of PN Therapy?

When injected in small quantities in the superficial dermis, it provides the following benefits to the skin:

  • Achieve smoother, firmer skin by improving skin elasticity and reducing appearance of wrinkles and fine lines
  • Reverse the ageing clock by repairing damaged skin cells to keep the skin young and radiant
  • Strengthening and thickening the foundational layers of the skin
  • Promote regeneration of new skin cells

Because of its natural skin-rejuvenating and healing effects, PN Skin Therapy treatment is often used by doctors to treat the following conditions, often with very good results:

  • Dark eye circles
  • Enlarged pores
  • Wrinkles and fine lines
  • Acne scars
  • Skin laxity
  • Dehydrated skin

What does PN Skin Therapy entail?

Topical numbing cream is applied on the skin. When the numbing sets in, the doctor uses a fine needle to administer tiny amounts of PN Skin Therapy under the skin. The treatment takes about 10 to 15 minutes to complete. After the treatment, the skin will be treated to our in-house specialty face mask to sooth the skin and reduce the redness and swelling.

What can I expect after the treatment?

You may get some mild swelling at the injection sites. However, the redness and swelling should be significantly reduced with LED Red Light Therapy. Most people can go back to work after the treatment. It is also important to understand that this treatment does not involve facial augmentation using dermal fillers, therefore you are unlikely to see any visible results instantly.

Skin healing process usually takes about 4 weeks to take effect and repair the skin from the inside. As Rejuran Healer treatment is essentially a skin-healing procedure using salmon DNA, you can expect to see gradual improvement of skin tone and texture over the next 4 to 6 weeks post-treatment. To yield the full benefits of Rejuran Healer treatment, it is advisable to undergo Rejuran Skin Healing Programme of 4 sessions about 3 weeks apart. This is to ensure that the results are long-lasting and sustainable.

What is the downtime?

There may be some visible raised bumps on the treated areas that may last for a few hours to a day. Temporary bruising, bruising and swelling may occur but these are not expected to last beyond 1-2 days.

Who should not undergo PN Skin Therapy?

As the contents of PN Skin Therapy are harvested from a fish source, people who are allergic to fish or seafood should avoid this treatment.

How long does PN Skin Therapy last?

The efficacy of the treatment after 1 session should last 4 to 6 months. If you complete a programme of about 3-4 sessions 4 weeks apart, you can expect the result to last for up to 12 months.

This looks similar to SkinBoosters. What is the difference?

Although both treatments are administered in a rather similar manner, they have different functions and work quite differently. SkinBoosters using hyaluronic acid dermal fillers to moisturise the skin by administering tiny amounts in the superficial layer of the skin. This treatment gives the skin a smoother appearance by plumping up the skin, which leads to reduced appearance of fine lines. On the other hand, PN Skin Therapy takes a more aggressive approach to anti-ageing. It repairs and heals damaged skin cells and reverses signs of ageing to keep the skin young and healthy. In conclusion, both SkinBoosters and PN Skin Therapy work in very different ways to address ageing and promote skin rejuvenation. Combining both treatments can achieve better anti-ageing and skin rejuvenation effects.


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    Improve overall skin tone and texture
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    Speed up wound healing process
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    Initiate skin repair by reducing signs of ageing such as wrinkles, fine lines
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    Achieve healthy, smooth skin with improved elasticity
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    Improve skin texture by minimising pores

Best For

People with severely aged skin who wish to undergo non-surgical treatment to repair the skin from within. PN Skin Therapy is also a suitable treatment for people with dull, patchy skin with wrinkles and fine lines. Adults with scars can also achieve good wound healing results with this treatment. Overall, PN Skin Therapy is a great option for people who wish to achieve age-reversal and youth-regenerating effects non-surgically.

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