Polynucleotide (PN) Skin Therapy
Polynucleotide Skin Treatment for Skin Quality, Repair and Rejuvenation
Rejuran Healer is an injectable polynucleotide treatment used to support skin quality, texture, elasticity and overall skin condition.
Unlike dermal fillers, Rejuran is not primarily designed to add facial volume or change facial shape.
Instead, treatment focuses on improving the skin itself. The treatment is part of a broader category of polynucleotide or PN injectable treatments, which are used in aesthetic medicine to support skin repair and gradual improvement in skin quality.
What Is Rejuran Healer?
Rejuran Healer is an injectable treatment containing polynucleotides derived from salmon DNA.
Polynucleotides are purified DNA fragments used in regenerative and skin-quality treatments.
Rather than producing immediate facial augmentation, Rejuran is used to support gradual improvement in the skin.
Its role is different from dermal filler.
Dermal fillers are mainly used for:
- facial volume
- structural support
- contouring
- feature enhancement
Rejuran is mainly used for:
- skin texture
- elasticity
- fine lines
- overall skin quality
- skin resilience
This distinction is important because patients sometimes assume all injectable treatments work in the same way.
They do not.
What Are Polynucleotides?
Polynucleotides, commonly abbreviated as PN, are chains of DNA fragments used in regenerative aesthetic treatments.
They are intended to support processes associated with:
- skin repair
- fibroblast activity
- collagen support
- hydration
- tissue recovery
- overall skin quality
The result is generally gradual rather than immediate.
Patients should not expect the volumising effect associated with dermal fillers.
How Does Rejuran Work?
Rejuran is injected into the skin through a series of small injection points.
The polynucleotides are delivered into the treated area to support the skin’s regenerative environment.
Over time, treatment may help improve:
- skin texture
- elasticity
- smoothness
- fine lines
- hydration
- enlarged-pore appearance
- overall skin condition
The current page already describes Rejuran as a treatment that works gradually rather than through instant filling or lifting, which is an important distinction to preserve.
What Can Rejuran Help With?
FINE LINES Rejuran may help soften the appearance of fine lines by supporting improvements in skin quality and elasticity. It is not the same as botulinum toxin for expression lines, and it does not replace dermal filler where volume loss is the main problem.
UNEVEN SKIN TEXTURE Patients with rough or uneven skin texture may consider PN treatment as part of a broader skin-quality plan. If texture changes are caused primarily by acne scars, pores or significant sun damage, other treatments may also be needed.
REDUCED SKIN ELASTICITY Polynucleotide treatment may be considered where the skin feels thinner, less resilient or less elastic.
ENLARGED PORES Improvement in skin texture and elasticity may make pores appear less obvious in some patients. However, PN treatment does not physically “close” pores.
DULL-LOOKING SKIN Improving overall skin condition may help the skin appear healthier and more refreshed over time.
DEHYDRATED SKIN PN treatments may contribute to improved skin hydration, although traditional HA skin boosters are usually more directly hydration-focused.
Rejuran and Acne-Scarred Skin
Rejuran may improve the overall quality of skin surrounding acne scars.
However, it should not be viewed as a primary treatment for deeper atrophic acne scars.
Depending on scar type, treatment may instead require:
- subcision
- RF microneedling
- fractional CO₂ laser
- TCA CROSS
PN treatment may sometimes be used alongside scar-specific treatments where improving surrounding skin quality is part of the overall plan.
Learn about acne scar treatment in Singapore →
Rejuran for the Under-Eye Area
The under-eye region is a common area of concern because the skin is thin and can show:
- fine lines
- crepiness
- texture changes
- loss of elasticity
Certain PN formulations may be considered for the peri-orbital area.
However, not every tired-looking eye is caused by poor skin quality.
Concerns such as:
- eye bags
- tear trough hollowing
- pigmentation
- swelling
may require a different treatment approach.
The under-eye area should therefore be assessed carefully before treatment.
Rejuran vs Skin Booster: What Is the Difference?
Rejuran and skin boosters are both injectable skin treatments, but they work differently.
REJURAN/ PN TREATMENT Primarily focused on:
- skin repair
- elasticity
- texture
- overall skin condition
- regenerative skin support
HA SKIN BOOSTER Primarily focused on:
- hydration
- skin smoothness
- suppleness
- fine dehydration lines
- radiance
Neither is automatically better.
A patient with persistent dehydration may benefit more from an HA skin booster, while someone with broader concerns relating to skin quality, texture or elasticity may be assessed for PN treatment.
Learn about skin booster treatment in Singapore →
Rejuran vs Dermal Filler
Rejuran is not a dermal filler.
Dermal filler is generally used to:
- replace facial volume
- improve projection
- support facial contours
- enhance selected features
Rejuran is used to improve skin quality rather than facial structure.
A patient with volume loss may therefore need filler, while a patient with textural or elasticity concerns may be more suitable for Rejuran or another skin-quality treatment.
Learn about dermal fillers in Singapore →
Rejuran vs Other Polynucleotide Injectables
Rejuran is one type of PN treatment.
Other polynucleotide formulations are also available and may differ in:
- concentration
- purity
- formulation
- injection technique
- treatment indication
At Radium Medical Aesthetics, patients may also be assessed for highly purified polynucleotide treatments depending on their skin condition and treatment goals.
Rather than choosing a PN product based solely on brand, the treatment should be selected according to the skin concern being treated.
Is Rejuran Safe?
Rejuran is an injectable medical treatment and possible side effects and complications can occur.
Common temporary effects may include:
- redness
- swelling
- tenderness
- bruising
- injection-site bumps
Less common complications may include:
- infection
- prolonged swelling
- inflammatory reactions
- lumps or other injection-related complications
A medical consultation is important to assess suitability and discuss risks before treatment.
Rejuran and Fish or Seafood Allergy
Because Rejuran is derived from salmon DNA, patients with a known fish or seafood allergy should inform the doctor before treatment.
Your doctor can assess whether Rejuran is appropriate or whether another skin-quality treatment should be considered instead.
Dr Siew Tuck Wah's Approach to PN Treatments
At Radium Medical Aesthetics, PN treatment is recommended according to the patient’s skin condition rather than simply because the treatment is popular.
Dr Siew Tuck Wah assesses factors such as:
- skin thickness
- hydration
- texture
- elasticity
- fine lines
- scarring
- age-related skin changes
The objective is to determine whether Rejuran, another PN injectable, a skin booster, laser, energy-based treatment or combination approach is most appropriate.
The treatment plan is therefore based on what the skin actually needs rather than using the same injectable for every patient.
Learn about Dr Siew Tuck Wah →
Frequently Asked Questions About Rejuran in Singapore
Benefits
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Supports improvement in overall skin quality -
Helps improve skin texture and elasticity
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May soften fine lines
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May improve the appearance of enlarged pores in selected patients
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Can improve overall skin smoothness
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Provides gradual skin-quality improvement without significant facial volumisation
Best For
People concerned about reduced skin quality, fine lines, uneven texture or loss of elasticity who are looking for a regenerative injectable treatment rather than facial volume enhancement.
