Highly Purified Polynucleotide (PN) Injectables
Regenerative PN Injectables for Skin Quality, Texture and Elasticity
Depending on the patient’s concerns, highly purified PN treatment may be considered for:
- fine lines
- uneven skin texture
- reduced skin elasticity
- dull-looking skin
- dehydration
- visible pores
- age-related changes in skin quality
At Radium Medical Aesthetics, the skin is assessed before treatment to determine whether a highly purified PN injectable, traditional skin booster or another skin-quality treatment may be more appropriate.
What Are Highly Purified Polynucleotide Injectables?
Polynucleotides are purified DNA fragments used in regenerative aesthetic treatments.
They are intended to support processes associated with:
- skin repair
- fibroblast activity
- collagen support
- hydration
- tissue quality
Different PN formulations may vary in:
- source
- concentration
- purity
- viscosity
- injection technique
- intended treatment area
At Radium Medical Aesthetics, one of the highly purified PN formulations used is Plinest, an Italian-manufactured polynucleotide injectable.
Rather than choosing a treatment based on brand alone, the more important consideration is whether the formulation is appropriate for the patient’s skin condition and treatment objective.
Learn more about polynucleotide treatment →
How Does Highly Purified PN Treatment Work?
Highly purified PN is injected into the skin through multiple small injection points.
Once administered, the polynucleotides are used to support the skin’s regenerative environment and processes associated with fibroblast activity and collagen support.
Over time, patients may notice gradual improvements in:
- skin texture
- elasticity
- smoothness
- fine lines
- hydration
- overall skin quality
The effect is gradual rather than immediate.
Unlike dermal filler, PN treatment does not primarily produce instant volume or projection.
What Can Highly Purified PN Treatment Help With?
FINE LINES PN treatment may help soften the appearance of fine lines by supporting improvements in skin quality and elasticity. It is not the same as botulinum toxin for expression lines or dermal filler for structural volume loss.
REDUCED SKIN ELASTICITY Highly purified PN may be considered where the skin feels thinner, less resilient or less elastic.
UNEVEN SKIN TEXTURE Patients concerned about rough or uneven texture may consider PN treatment as part of a broader skin-quality plan.
VISIBLE PORES Improvement in overall skin texture and elasticity may make pores appear less noticeable in some patients. However, PN treatment does not physically “close” pores.
DULL-LOOKING SKIN Gradual improvement in skin quality may help the skin appear healthier and more refreshed.
DEHYDRATED SKIN PN treatments may support hydration, although conventional hyaluronic acid skin boosters remain more directly focused on improving skin hydration.
Highly Purified PN and Ageing Skin
Skin ageing is influenced by more than one factor.
Changes may occur in:
- collagen
- elasticity
- hydration
- skin thickness
- pigmentation
- texture
- structural support
PN injectables are primarily used where the treatment objective is to improve skin quality rather than facial structure.
Where significant laxity, pigmentation or volume loss is present, another treatment may be more appropriate.
Highly Purified PN and Acne-Scarred Skin
Highly purified PN treatment may support the quality of skin surrounding acne scars.
However, it should not be considered a primary treatment for deeper atrophic acne scars.
Depending on scar type, treatment may require procedures such as:
- subcision
- RF microneedling
- fractional CO₂ laser
- TCA CROSS
PN treatment may sometimes be incorporated into a broader treatment plan where improving surrounding skin quality is also an objective.
Learn more about acne scar treatment Singapore →
Can Highly Purified PN Be Used Under the Eyes?
Certain PN formulations may be considered for the peri-orbital or under-eye region.
The skin around the eyes is thin and may show:
- fine lines
- crepiness
- reduced elasticity
- textural changes
However, not every tired-looking eye is caused by poor skin quality.
Under-eye concerns may also be related to:
- tear trough hollowing
- eye bags
- pigmentation
- swelling
- skin laxity
The underlying cause should therefore be assessed before deciding whether PN treatment is appropriate.
Highly Purified PN vs Skin Booster
Highly purified PN injectables and traditional skin boosters are both used to improve skin quality, but they work differently.
HIGHLY PURIFIED PN Primarily focused on:
- regenerative skin support
- elasticity
- texture
- fine lines
- overall skin condition
HA SKIN BOOSTER Primarily focused on:
- hydration
- smoothness
- suppleness
- fine dehydration lines
- radiance
A patient whose main concern is persistent dehydration may be better suited to an HA skin booster. Someone with broader concerns relating to texture, elasticity or skin quality may be assessed for a PN treatment. Neither is automatically better.
Learn more about skin booster treatment in Singapore →
Highly Purified PN vs Dermal Filler
Highly purified PN is not a dermal filler.
Dermal fillers are generally used to:
- restore facial volume
- provide structural support
- enhance contours
- improve facial proportions
PN injectables are instead used to improve skin quality. A patient with significant facial volume loss may therefore need filler, while someone concerned about skin texture or elasticity may be more suited to PN treatment.
Learn more about dermal fillers in Singapore →
Which Areas Can Be Treated?
Treatment areas depend on the patient’s skin condition and the formulation selected.
Areas that may be considered include:
- face
- under-eye region
- neck
- décolletage
- selected areas of reduced skin quality
Not every product or injection technique is suitable for every area. Treatment should therefore be individualised.
Fish Allergy and PN Treatments
Some polynucleotide formulations are derived from fish DNA.
Patients with known fish or seafood allergies should therefore inform their doctor before treatment. The doctor can assess whether the selected PN formulation is appropriate or whether another skin-quality treatment should be considered.
Dr Siew Tuck Wah's Approach to PN Injectables
At Radium Medical Aesthetics, PN treatments are selected according to the patient’s skin condition rather than simply according to brand.
Dr Siew Tuck Wah may assess factors such as:
- skin thickness
- hydration
- elasticity
- texture
- fine lines
- age-related changes
- treatment area
The objective is to determine whether a highly purified PN injectable, another PN formulation, an HA skin booster or another treatment approach is most appropriate.
Not every patient requires the same injectable.
Learn more about Dr Siew Tuck Wah →
Benefits
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Improve overall skin tone and texture -
Reduce visible enlarged pores and oily skin
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Reduce apperance of wrinkles and fine lines
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Induce deep skin repair at cellular level
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Achieve healthy, smooth skin with improved elasticity
Best For
People who are experiencing premature skin ageing with several skin conditions such as skin sensitivity, enlarged pores, oily skin, wrinkles, and acne.
PN treatment would be suitable those who wish to address several skin issues all at the same time. In addition, people who have acne scars can also achieve good wound healing results with PN treatment.
Overall, PN treatment is a great option for people who wish to achieve age-reversal and youth-regenerating effects non-surgically.
