Highly Purified Polynucleotide (PN) Treatment in Singapore

Radium Aesthetic

Aesthetic Treatments

Highly Purified Polynucleotide (PN) Injectables

Induce Intense Skin Repair and Regenerate Collagen Production

Highly purified polynucleotide injections have emerged as a therapeutic solution in regenerative medicine. These injections are made using Polynucleotide Highly Purified Technology or PN-HPT, which are essential for reducing visible signs of premature ageing, such as wrinkles, fine lines, enlarged pores, and pigmentation.

The injections work on cellular level to repair damaged tissue and regenerate collagen to maintain a youthful complexion, by stimulating fibroblasts which encourage cell renewal, improve skin elasticity, and enhance overall skin quality. With their powerful wound-healing properties, they are also an effective treatment for people with skin redness, sensitivty and even acne. 

Highly Purified and other PN injectables

At Radium, the type of highly purified PN injectable we use is Plinest. Plinest was invented and manufactured by an Italian pharmaceutical company called Mastelli. 

It contains DNA fragments of farm-bred Italian trout fish. Harvested using its PN-HPT technology, Plinest is able to extract only the purest and most effective active compounds. 

Plinest is CE-marked for excellent human compatibility and its safety profile since 2005.

It was also found that Plinest is particularly useful for people who have fibrous old scar tissue and stretch marks. Such old scars are often challenging to treat. With Plinest, visible improvements of old scars and uneven skin texture can be seen after the first session of Plinest treatment.

On top of its abilty of induce deep skin repair and collagen production, Plinest has hydrating and viscoelastic properties to improve overall skin tone and texture.

How Does Highly purified PN injectable Benefit My skin?

CELLULAR REPAIR Once injected into the skin, it sets off a chain of skin rejuvenative actions within the skin at the cellular level. As we experience intrinsic and extrinsic skin ageing on a daily basis, highly purified PN injectable helps to reverse and slow down the ageing process, restoring these cells to their optimal level.

RESTORES COLLAGEN Collagen plays one of the most imporant roles in anti-ageing by strengthening the foundation and preventing wrinkles from forming. It also helps to retain moisture in the skin to prevent dehydration. 

IMPROVE OVERALL SKIN HEALTH A compromised skin barrier allows external factors to break down your skin tissue, making your skin ageing to accelerate faster than usual. With regular highly purified PN injectable treatment, it helps to thicken the foundational layers of the skin, giving you ample protection from external factors such as UV rays and pollution. For some people, they see visible improvement in their melasma as well when the overall skin health is better. 

Are Highly Purified PN Injectables considered dermal fillers or skin boosters?

Highly purified PN injectables do not work the same way as a HA dermal filler or a collagen-stimulating dermal filler.

The aim of these injectables is not to volumise your face or augment any part of your facial features. Instead, they use PN or polynucleotides to rejuvenate and repair the skin by providing hydration, elasticity, and a host of anti-ageing benefits. 

In general, SkinBoosters is a type of injectable treatment that aims to deeply hydrate the skin. It usually contains very watery pure HA that is injected superficially into various points of the face to achieve long-lasting hydration. 

Highly purified PN injectables work the same way in the sense that they are also administered into various points on the face. Similar to SkinBoosters, it is recommended to get 3 treatments, one month apart. After that, you can opt for a 6-monthly maintainance for SkinBoosters and/or PN injectables.


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    Improve overall skin tone and texture
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    Reduce visible enlarged pores and oily skin
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    Reduce apperance of wrinkles and fine lines
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    Induce deep skin repair at cellular level
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    Achieve healthy, smooth skin with improved elasticity

Best For

People who are experiencing premature skin ageing with several skin conditions such as skin sensitivity, enlarged pores, oily skin, wrinkles, and acne. 

PN treatment would be suitable those who wish to address several skin issues all at the same time. In addition, people who have acne scars can also achieve good wound healing results with PN treatment. 

Overall, PN treatment is a great option for people who wish to achieve age-reversal and youth-regenerating effects non-surgically.

Frequently asked questions about Plinest treatment in Singapore

What is the difference between PN Injectables and SkinBoosters?

SkinBoosters is generally made of watery pure HA that is injected superficially into the skin layers to immediately boost hydration and reduce appearance of wrinkles and fine lines. 

On the other hand, highly purified PN injectables work by inducing skin repair and kickstarting the collagen regeneration to reverse all signs of skin ageing. They also help to reduce appearance of scars and pigmentation. 

How much do highly purified PN injectables Cost?

This treatment is priced at about $800 to $900 per syringe. 

How often do I need to undergo highly purified PN injectable treatments?

For first-timers, we recommend that you undergo a programme of 3 sessions, with each session about 4 weeks apart. 

Once the initial programme is completed, you should opt for a session every 6 months to maintain the results of the treatment. 

Am I A Suitable Candidate For highly purified PN injectables?

This treatment is best suited for people in their mid-thirties who may be experiencing early signs of premature ageing such as enlarged pores, skin sensitivty, wrinkles, pigmentation, scars etc.

Is there any downtime after highly purified PN injectable treatment?

This entire process is a very comfortable 45-minute treatment. As our doctors use cannula to administer highly purified PN injectables, there will be minimal risk and discomfort during the treatment. 

You may experience some skin redness and swelling immediately after the treatment. However, these side effects should resolve very quickly within the same day.

Can vegetarians or vegans undergo highly purified PN injectable treatment?

Highly purified PN injectables are derived from the DNA fragments of Italian trout fish. 

Hence, they may not be suitable for vegetarians or vegans. 

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